Abstract: By introducing a new model integrated Cloud computing with P2P computing named Cloud-P2P into the mechanism, a large-scale virus report analysis mechanism based on the Cloud-P2P architecture is proposed. The massive computing power of terminals can be further utilized by the mechanism. The mechanism divides the large-scale jobs of virus analysis reports effectively, and deploys tasks to servers and terminals to implement with mobile agents, which effectively reduce the server loads and improve the overall system efficiency. The Cloud-P2P model, the mobile-agent-based deployment mechanism, the execution point selection mechanism and the prototype system are elaborated in detail. The system performance was analyzed from the following aspects: the load balancing, security and reliability. The conclusions show that the mechanism has a good theoretical and practical reference value.