Abstract: Tire pressure monitor system(TPMS) of vehicles with high reliability and having good real-time is designed, considering the characteristics of vehicle tire pressure. Embedded real-time operating system μC/OS-II is adopted as the software platform, with software designed in multi-task, and 32 bit embedded ARM processor is used. Accident can be prevented effectively when a tire from running out of normal pressure for long hours, and automobile active safety is increased. This tire pressure monitoring system provides an advantageous and reliable solution for tire pressure monitoring system.