Abstract: Based on China, Russia, India and Brazil 1990-2010 data as a sample, this study uses the VAR model to research the interaction between the brain drain and economic growth. The results show that: first, the economic growth will suppress brain drain; second, on the surface, economic growth on the impact of brain drain reaction displays some positive effects, because of an open talent policy promoting international talent mobility and economic growth. More financial investment and more open policy environment allow us to suppress brain drain and improve the level of economic development.